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pentobarbital will reduce the extent or result of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers cuts down plasma focus of abemaciclib and its metabolites.pentobarbital will lower the level or impact of paclitaxel protein certain